Metformin ER
Longevity therapeutic targeting mTOR and AMPK pathways. Prescription only.
Dose & timing
- 1,000 mg — morning
- 500 mg — with dinner
Why it appeared in the archived stack
Activates AMPK, inhibits mTORC1 indirectly, improves insulin sensitivity. The TAME trial (Targeting Aging with Metformin) is the marquee longevity rationale; Bryan uses extended-release to flatten the GI side-effects.
Lower second dose. Splitting 1.5 g/day across AM + PM smooths the lactate curve and improves GI tolerance vs. one bolus. Same TAME-trial longevity rationale as the morning dose.
Related supplements
FAQ
Can I buy Metformin ER on Amazon?
No. Metformin ER is a prescription item, so it isn't sold on Amazon and this page provides no purchase links. Talk to a qualified doctor before considering it.
What dose of Metformin ER appeared in the January 2024 protocol?
1,000 mg — morning; 500 mg — with dinner.
Why did Metformin ER appear in the archived stack?
Activates AMPK, inhibits mTORC1 indirectly, improves insulin sensitivity. The TAME trial (Targeting Aging with Metformin) is the marquee longevity rationale; Bryan uses extended-release to flatten the GI side-effects.