Metformin ER
Longevity therapeutic targeting mTOR and AMPK pathways. Prescription only.
Dose & timing
- 1,000 mg — morning
- 500 mg — with dinner
Why it’s in the stack
Activates AMPK, inhibits mTORC1 indirectly, improves insulin sensitivity. The TAME trial (Targeting Aging with Metformin) is the marquee longevity rationale; Bryan uses extended-release to flatten the GI side-effects.
Lower second dose. Splitting 1.5 g/day across AM + PM smooths the lactate curve and improves GI tolerance vs. one bolus. Same TAME-trial longevity rationale as the morning dose.
Related supplements
FAQ
Can I buy Metformin ER on Amazon?
No. Metformin ER is a prescription item, so it isn't sold on Amazon and this page provides no purchase links. Talk to a qualified doctor before considering it.
What dose of Metformin ER does the Blueprint protocol use?
1,000 mg — morning; 500 mg — with dinner.
Why is Metformin ER in the longevity stack?
Activates AMPK, inhibits mTORC1 indirectly, improves insulin sensitivity. The TAME trial (Targeting Aging with Metformin) is the marquee longevity rationale; Bryan uses extended-release to flatten the GI side-effects.